variantMTB Report -Tiers-

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Tier 1 - Variants of Strong Clinical Significance -

The Prioritization of Variants into Tiers is based on the Standards and Guidelines of the AMP.
Variants in Tier 1 are described as therapeutic, diagnostic or prognostic biomarkers
with an Evidence Level of A or B in at least one of the queried Knowledgebases.

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Tier 2 - Variants of Potential Clinical Significance -

The Prioritization of Variants into Tiers is based on the Standards and Guidelines of the AMP.
Variants in Tier 2 are described as therapeutic, diagnostic or prognostic biomarkers
with an Evidence Level of C or D in at least one of the queried Knowledgebases.

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Tier 3 - Variants of Unknown Clinical Significance

The Prioritization of Variants into Tiers is based on the Standards and Guidelines of the AMP.
Variants in Tier 3 are not necessarily described with therapeutic, diagnostic or prognostic evidence.
If so, the CIViC evidence level is E. Other variants in Tier 3 are considered oncogenic in the CGI Knowledgebase
and are not observed at a significant allele frequency in the general population.

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